ChloroquineV1, France, Analysis, bibRecord, 000238

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

Identifieur interne : 000238 ( France/Analysis ); précédent : 000237; suivant : 000239

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

Auteurs : Pieter Leyssen [Belgique] ; Marc Litaudon [France] ; Jean-Claude Guillemot [France] ; Philippe Rasoanaivo [Madagascar] ; Jacqueline Smadja [Réunion] ; Ameenah Gurib-Fakim ; Bruno Canard [France] ; Françoise Guéritte [France]

Source :

Antiviral Research [ 0166-3542 ] ; 2011.

RBID : Hal:hal-01187697

Abstract

Chikungunya virus (CHIKV) is an alphavirus that is transmitted to humans mainly by the Aedes aegypti or albopictus mosquito. Ever since the outbreak on Reunion Islands in 2005–2006, CHIKV is considered to be an emerging virus. In particular arthralgia or arthritis, affecting multiple joints, is very pronounced during the clinical course, and may last for as long as 2 years. Currently, no vaccine nor a selective antiviral drug is available for the prevention or treatment of this debilitating viral infection. Chloroquine is active in cell culture and may alleviate the symptoms of arthritis by acting as an anti-inflammatory agent, although this latter is still under investigation. In 2008, the CRVOI (Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien) has funded a research program that brings together four areas of expertise: the use of plants as natural source for the treatment of disease (ethnopharmacology), the identification and classification of plant species biodiversity, the purification and identification of unique molecules/secondary metabolites of natural origin, and the identification and characterisation of selective inhibitors of virus replication. Three teams, located on Reunion Islands, Mauritius and Madagascar, together with the ICSN, have build a unique sample library consisting out of more than 1500 crude plant extracts that have been evaluated for selective antiviral activity against CHIKV in Leuven and Marseille. Currently, a bio-assay-guided purification of pure substances is in progress, at present yielding the first results. Concomitantly, enzymatic assays are being developed in Marseille to evaluate and possibly characterize in detail the selective inhibitory effect of these compounds.

Url:

https://hal.univ-reunion.fr/hal-01187697

DOI: 10.1016/j.antiviral.2011.03.048

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000180
to stream Hal, to step Curation: 000180
to stream Hal, to step Checkpoint: 000172
to stream Main, to step Merge: 001466
to stream Main, to step Curation: 001464
to stream Main, to step Exploration: 001464
to stream France, to step Extraction: 000238

Links to Exploration step

Hal:hal-01187697

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication</title>
<author><name sortKey="Leyssen, Pieter" sort="Leyssen, Pieter" uniqKey="Leyssen P" first="Pieter" last="Leyssen">Pieter Leyssen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-28529" status="INCOMING">          <orgName>Department of Microbiology and Immunology, Rega Institute for Medical Research</orgName>
          <desc>            <address>              <addrLine>10, Minderbroedersstraat B-3000 Leuven</addrLine>
              <country key="BE"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300656" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300656" type="direct"><org type="institution" xml:id="struct-300656" status="VALID">          <orgName>Catholic University of Leuven - Katholieke Universiteit Leuven</orgName>
          <orgName type="acronym">KU Leuven</orgName>
          <desc>            <address>              <addrLine>Oude Markt 13 - bus 5005, 3000 Leuven</addrLine>
              <country key="BE"></country>
            </address>
            <ref type="url">http://www.kuleuven.be/english/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Belgique</country>
</affiliation>
</author>
<author><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Guillemot, Jean Claude" sort="Guillemot, Jean Claude" uniqKey="Guillemot J" first="Jean-Claude" last="Guillemot">Jean-Claude Guillemot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199349" status="OLD">          <idno type="IdRef">149981651</idno>
          <idno type="RNSR">201220260Z</idno>
          <orgName>Architecture et fonction des macromolécules biologiques</orgName>
          <orgName type="acronym">AFMB</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Faculté des Sciences de Luminy - Case 932 163, Avenue de Luminy13288 Marseille Cedex 09</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.afmb.univ-mrs.fr/</ref>
          </desc>
          <listRelation>            <relation name="UMR7257" active="#struct-92114" type="direct"></relation>
            <relation name="UMR7257" active="#struct-198056" type="direct"></relation>
            <relation name="UMR7257" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR7257" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Rasoanaivo, Philippe" sort="Rasoanaivo, Philippe" uniqKey="Rasoanaivo P" first="Philippe" last="Rasoanaivo">Philippe Rasoanaivo</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-236226" status="INCOMING">          <orgName>Laboratoire de Biothérapeutique</orgName>
          <desc>            <address>              <addrLine>BP 3833, 101-Antananarivo</addrLine>
              <country key="MG"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-308083" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-308083" type="direct"><org type="institution" xml:id="struct-308083" status="INCOMING">          <orgName>Institut Malgache de Recherches Appliquées</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Madagascar</country>
</affiliation>
</author>
<author><name sortKey="Smadja, Jacqueline" sort="Smadja, Jacqueline" uniqKey="Smadja J" first="Jacqueline" last="Smadja">Jacqueline Smadja</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-109875" status="VALID">          <idno type="RNSR">199613793P</idno>
          <orgName>Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments</orgName>
          <orgName type="acronym">LCSNSA</orgName>
          <desc>            <address>              <addrLine>Faculté des Sciences et techniques - Université de La Réunion 15 avenue René Cassin CS92003 97744 SAINT DENIS CEDEX 9</addrLine>
              <country key="RE"></country>
            </address>
          </desc>
          <listRelation>            <relation name="EA2212" active="#struct-300316" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="EA2212" active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID">          <orgName>Université de La Réunion</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>            <address>              <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
              <country key="RE"></country>
            </address>
            <ref type="url">http://www.univ-reunion.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Gurib Fakim, Ameenah" sort="Gurib Fakim, Ameenah" uniqKey="Gurib Fakim A" first="Ameenah" last="Gurib-Fakim">Ameenah Gurib-Fakim</name>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199349" status="OLD">          <idno type="IdRef">149981651</idno>
          <idno type="RNSR">201220260Z</idno>
          <orgName>Architecture et fonction des macromolécules biologiques</orgName>
          <orgName type="acronym">AFMB</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Faculté des Sciences de Luminy - Case 932 163, Avenue de Luminy13288 Marseille Cedex 09</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.afmb.univ-mrs.fr/</ref>
          </desc>
          <listRelation>            <relation name="UMR7257" active="#struct-92114" type="direct"></relation>
            <relation name="UMR7257" active="#struct-198056" type="direct"></relation>
            <relation name="UMR7257" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR7257" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Gueritte, Francoise" sort="Gueritte, Francoise" uniqKey="Gueritte F" first="Françoise" last="Guéritte">Françoise Guéritte</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01187697</idno>
<idno type="halId">hal-01187697</idno>
<idno type="halUri">https://hal.univ-reunion.fr/hal-01187697</idno>
<idno type="url">https://hal.univ-reunion.fr/hal-01187697</idno>
<idno type="doi">10.1016/j.antiviral.2011.03.048</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Hal/Corpus">000180</idno>
<idno type="wicri:Area/Hal/Curation">000180</idno>
<idno type="wicri:Area/Hal/Checkpoint">000172</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000172</idno>
<idno type="wicri:doubleKey">0166-3542:2011:Leyssen P:phytochik:biodiversity:as</idno>
<idno type="wicri:Area/Main/Merge">001466</idno>
<idno type="wicri:Area/Main/Curation">001464</idno>
<idno type="wicri:Area/Main/Exploration">001464</idno>
<idno type="wicri:Area/France/Extraction">000238</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication</title>
<author><name sortKey="Leyssen, Pieter" sort="Leyssen, Pieter" uniqKey="Leyssen P" first="Pieter" last="Leyssen">Pieter Leyssen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-28529" status="INCOMING">          <orgName>Department of Microbiology and Immunology, Rega Institute for Medical Research</orgName>
          <desc>            <address>              <addrLine>10, Minderbroedersstraat B-3000 Leuven</addrLine>
              <country key="BE"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300656" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300656" type="direct"><org type="institution" xml:id="struct-300656" status="VALID">          <orgName>Catholic University of Leuven - Katholieke Universiteit Leuven</orgName>
          <orgName type="acronym">KU Leuven</orgName>
          <desc>            <address>              <addrLine>Oude Markt 13 - bus 5005, 3000 Leuven</addrLine>
              <country key="BE"></country>
            </address>
            <ref type="url">http://www.kuleuven.be/english/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Belgique</country>
</affiliation>
</author>
<author><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Guillemot, Jean Claude" sort="Guillemot, Jean Claude" uniqKey="Guillemot J" first="Jean-Claude" last="Guillemot">Jean-Claude Guillemot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199349" status="OLD">          <idno type="IdRef">149981651</idno>
          <idno type="RNSR">201220260Z</idno>
          <orgName>Architecture et fonction des macromolécules biologiques</orgName>
          <orgName type="acronym">AFMB</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Faculté des Sciences de Luminy - Case 932 163, Avenue de Luminy13288 Marseille Cedex 09</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.afmb.univ-mrs.fr/</ref>
          </desc>
          <listRelation>            <relation name="UMR7257" active="#struct-92114" type="direct"></relation>
            <relation name="UMR7257" active="#struct-198056" type="direct"></relation>
            <relation name="UMR7257" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR7257" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Rasoanaivo, Philippe" sort="Rasoanaivo, Philippe" uniqKey="Rasoanaivo P" first="Philippe" last="Rasoanaivo">Philippe Rasoanaivo</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-236226" status="INCOMING">          <orgName>Laboratoire de Biothérapeutique</orgName>
          <desc>            <address>              <addrLine>BP 3833, 101-Antananarivo</addrLine>
              <country key="MG"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-308083" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-308083" type="direct"><org type="institution" xml:id="struct-308083" status="INCOMING">          <orgName>Institut Malgache de Recherches Appliquées</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Madagascar</country>
</affiliation>
</author>
<author><name sortKey="Smadja, Jacqueline" sort="Smadja, Jacqueline" uniqKey="Smadja J" first="Jacqueline" last="Smadja">Jacqueline Smadja</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-109875" status="VALID">          <idno type="RNSR">199613793P</idno>
          <orgName>Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments</orgName>
          <orgName type="acronym">LCSNSA</orgName>
          <desc>            <address>              <addrLine>Faculté des Sciences et techniques - Université de La Réunion 15 avenue René Cassin CS92003 97744 SAINT DENIS CEDEX 9</addrLine>
              <country key="RE"></country>
            </address>
          </desc>
          <listRelation>            <relation name="EA2212" active="#struct-300316" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="EA2212" active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID">          <orgName>Université de La Réunion</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>            <address>              <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
              <country key="RE"></country>
            </address>
            <ref type="url">http://www.univ-reunion.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Gurib Fakim, Ameenah" sort="Gurib Fakim, Ameenah" uniqKey="Gurib Fakim A" first="Ameenah" last="Gurib-Fakim">Ameenah Gurib-Fakim</name>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199349" status="OLD">          <idno type="IdRef">149981651</idno>
          <idno type="RNSR">201220260Z</idno>
          <orgName>Architecture et fonction des macromolécules biologiques</orgName>
          <orgName type="acronym">AFMB</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Faculté des Sciences de Luminy - Case 932 163, Avenue de Luminy13288 Marseille Cedex 09</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.afmb.univ-mrs.fr/</ref>
          </desc>
          <listRelation>            <relation name="UMR7257" active="#struct-92114" type="direct"></relation>
            <relation name="UMR7257" active="#struct-198056" type="direct"></relation>
            <relation name="UMR7257" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR7257" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7257" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Gueritte, Francoise" sort="Gueritte, Francoise" uniqKey="Gueritte F" first="Françoise" last="Guéritte">Françoise Guéritte</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.antiviral.2011.03.048</idno>
<series><title level="j">Antiviral Research</title>
<idno type="ISSN">0166-3542</idno>
<imprint><date type="datePub">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Chikungunya virus (CHIKV) is an alphavirus that is transmitted to humans mainly by the Aedes aegypti or albopictus mosquito. Ever since the outbreak on Reunion Islands in 2005–2006, CHIKV is considered to be an emerging virus. In particular arthralgia or arthritis, affecting multiple joints, is very pronounced during the clinical course, and may last for as long as 2 years. Currently, no vaccine nor a selective antiviral drug is available for the prevention or treatment of this debilitating viral infection. Chloroquine is active in cell culture and may alleviate the symptoms of arthritis by acting as an anti-inflammatory agent, although this latter is still under investigation. In 2008, the CRVOI (Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien) has funded a research program that brings together four areas of expertise: the use of plants as natural source for the treatment of disease (ethnopharmacology), the identification and classification of plant species biodiversity, the purification and identification of unique molecules/secondary metabolites of natural origin, and the identification and characterisation of selective inhibitors of virus replication. Three teams, located on Reunion Islands, Mauritius and Madagascar, together with the ICSN, have build a unique sample library consisting out of more than 1500 crude plant extracts that have been evaluated for selective antiviral activity against CHIKV in Leuven and Marseille. Currently, a bio-assay-guided purification of pure substances is in progress, at present yielding the first results. Concomitantly, enzymatic assays are being developed in Marseille to evaluate and possibly characterize in detail the selective inhibitory effect of these compounds.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>France</li>
<li>Madagascar</li>
<li>Réunion</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Gurib Fakim, Ameenah" sort="Gurib Fakim, Ameenah" uniqKey="Gurib Fakim A" first="Ameenah" last="Gurib-Fakim">Ameenah Gurib-Fakim</name>
</noCountry>
<country name="Belgique"><noRegion><name sortKey="Leyssen, Pieter" sort="Leyssen, Pieter" uniqKey="Leyssen P" first="Pieter" last="Leyssen">Pieter Leyssen</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name>
</noRegion>
<name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<name sortKey="Gueritte, Francoise" sort="Gueritte, Francoise" uniqKey="Gueritte F" first="Françoise" last="Guéritte">Françoise Guéritte</name>
<name sortKey="Guillemot, Jean Claude" sort="Guillemot, Jean Claude" uniqKey="Guillemot J" first="Jean-Claude" last="Guillemot">Jean-Claude Guillemot</name>
</country>
<country name="Madagascar"><noRegion><name sortKey="Rasoanaivo, Philippe" sort="Rasoanaivo, Philippe" uniqKey="Rasoanaivo P" first="Philippe" last="Rasoanaivo">Philippe Rasoanaivo</name>
</noRegion>
</country>
<country name="Réunion"><noRegion><name sortKey="Smadja, Jacqueline" sort="Smadja, Jacqueline" uniqKey="Smadja J" first="Jacqueline" last="Smadja">Jacqueline Smadja</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000238 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000238 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:hal-01187697
   |texte=   PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri